An overview of proteomic and metabolomic technologies and.
Purpose: Neuroblastoma is a childhood malignancy originating from the sympathetic nervous system with a complex biology, prone to metastasize and relapse. High-risk, metastatic cases are explained in part by amplification or mutation of oncogenes, such as MYCN and ALK, and loss of tumor suppressor genes in chromosome band 1p. However, it is fundamental to identify other pathways responsible.
Cytochrome P450 4F12 is a drug-metabolizing enzyme that is primarily expressed in the liver, kidney, colon, small intestine, and heart. The properties of CYP4F12 that may impart an increased catalytic selectivity (decreased promiscuity) were explored through in vitro metabolite elucidation, kinetic isotope effect experiments, and computational modeling of the CYP4F12 active site. By using.
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Authorship note: NZ and TG contributed equally to this work. Find articles by Zhang, N. A22189), according to the manufacturer’s instructions. Briefly, HepG2 cells were transfected with siCon or siH19 in a 24-well plate, followed by glucose output assay 48 hours later. For primary mouse hepatocytes, cells were infected with AAV-Vec or AAV-H19 in a 12-well plate, and glucose output assay.
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In academia, publication productivity, defined as the number of peer-reviewed articles published and the frequency of citations, is a primary factor in the assessment of tenure and promotion.
By using unique systems biology approaches, patient samples, and in vitro experiments, we provide novel evidence that pulmonary arterial hypertension (PAH) pathogenesis and bone morphogenetic protein receptor 2 (BMPR2) dysfunction in pulmonary endothelial cells are strongly linked to altered DNA damage control. We also show evidence that breast cancer 1 (BRCA1) is a novel downstream target of.
Optimum flowering time is a key agronomic trait in Brassica napus. To investigate the genetic architecture and genetic regulation of flowering time in this important crop, we conducted quantitative trait loci (QTL) analysis of flowering time in a recombinant inbred line (RIL) population, including lines with extreme differences in flowering time, in six environments, along with RNA-Seq.
Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of.
The tour of MVP functionality presented here works from input data produced within a Galaxy workflow. We have made workflows available to generate input data needed for a user to explore the functionality of MVP, along with documentation describing their operation (see Accessibility section for instructions and links to access these data).
The peptide spectra were detected with MALDI-TOF Voyager DE-STR (Applied Biosystems, Framingham, CA, USA). The general procedure related to MALDI-TOF was carried out according to Applied Biosystems' instructions, and the peptide peaks were analyzed by searching the ProteinProspector MS-FIT database.
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